While the traditional design, without considering the environmental effects, only focuses on the production and use of the product. A broader approach in environmental design is to examine and extract raw materials (pre-construction stage), reverse logistics and end-of-life impact in the design stage. Based on this, the aim of this article was to design a pattern of drivers for applying the strategy of environmental design of products in the pharmaceutical industry. The research method was a combination of qualitative and quantitative. In the qualitative part, based on theme analysis, the main drivers of using the environmental design strategy of products in the pharmaceutical industry have been identified. The tool of data collection in this section was interview. Sampling has been done in the form of theoretical saturation. In the quantitative part, the pattern of relationships between the main drivers of using the environmental design strategy of products has been formulated. Data analysis has been done in the quantitative part based on confirmatory factor analysis and interpretive structural modeling. The data collection in the quantitative section was done based on two questionnaires. The statistical population in the factor analysis section was 252 experts and managers of pharmaceutical companies. The number of samples is determined based on the table of Krejci and Morgan of 150 experts and managers. The research findings in the qualitative part showed seven main themes and 44 sub-themes. In the quantitative part, the results of the confirmatory factor analysis have shown the appropriateness of each of the confirmation