International protection of human rights, regardless of the global level, has also been considered at the regional level. In this case, regional intergovernmental organizations have ratified regional human rights instruments, the most prominent of which are the European, American and African human rights conventions. In order to monitor the proper implementation of human rights regulations, prevent any violation and infringement of the human rights of citizens of member states, and ultimately improve the status of human rights, these conventions have established executive mechanisms at the regional level and assigned them with competencies and tasks. Although these mechanisms have had an acceptable track record, they also face challenges. In the present article, an attempt has been made to identify and examine the most important and serious challenges facing regional human rights mechanisms and solutions to overcome the current situation. The implementation of human rights should be at the national and local levels, because the mechanisms of institutions based on international treaties have challenges and shortcomings that require continuous efforts to resolve. Therefore, strengthening these institutions can be considered one of the most important solutions.