The vast country of Iran played a significant role in establishing trade relations due to its importance as a strategic location and the presence of caravanserais as a place for merchants and traders to settle. The efficiency and attention paid to the construction of caravanserais played a significant role in the movement of trade caravans and the growth of trade in the country. Despite the construction of caravanserais in most historical periods in Iran, caravan construction increased significantly in the Safavid era. In this period, following the occurrence of some important events such as establishing security, building suitable roads, paying attention to pilgrimage routes and cities, granting religious freedom to religious minorities, and customs facilities, the entry of traders and trade caravans into the country increased. With the entry of trade caravans into Iran and the increase in caravan travel within the country, numerous caravanserais were built for residence by order of the Safavid kings. However, this period has many differences compared to the Qajar era. Although trade relations with various countries were resumed in the Qajar era, it never reached the level of previous trade relations (the Safavid era). During this period, a number of caravanserais were also established, but due to the haste in their construction and the use of inferior materials, especially brick, most of these buildings have been largely destroyed or completely destroyed today. The Silk Road route, as a vital and economic highway, was always of interest and a place of passage for trade caravans.